Cytotoxic Efficacy and Resistance Mechanism of a TRAIL and VEGFA-Peptide Fusion Protein in Colorectal Cancer Models

Cytotoxic Efficacy and Resistance Mechanism of a TRAIL and VEGFA-Peptide Fusion Protein in Colorectal Cancer Models

TNF-related apoptosis-inducing ligand (TRAIL) is a type II transmembrane protein capable of selectively inducing apoptosis in cancer cells by binding to its cognate receptors. Here, we examined the anticancer efficacy of a recently developed chimeric AD-O51.4 protein, a TRAIL fused to the VEGFA-orig...

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Bibliographic Details
Main Authors: Michal Kopczynski, Malgorzata Statkiewicz, Magdalena Cybulska, Urszula Kuklinska, Katarzyna Unrug-Bielawska, Zuzanna Sandowska-Markiewicz, Aleksandra Grochowska, Marta Gajewska, Maria Kulecka, Jerzy Ostrowski, Michal Mikula
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
TRAIL
colorectal cancer
PDX
apoptosis
Online Access:https://www.mdpi.com/1422-0067/22/6/3160

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https://www.mdpi.com/1422-0067/22/6/3160

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