MLN4924, a Protein Neddylation Inhibitor, Suppresses the Growth of Human Chondrosarcoma through Inhibiting Cell Proliferation and Inducing Endoplasmic Reticulum Stress-Related Apoptosis

MLN4924, a Protein Neddylation Inhibitor, Suppresses the Growth of Human Chondrosarcoma through Inhibiting Cell Proliferation and Inducing Endoplasmic Reticulum Stress-Related Apoptosis

Chondrosarcoma, a heterogeneous malignant bone tumor, commonly produces cartilage matrix, which generally has no response to conventional therapies. Studies have reported that MLN4924, a NEDD8-activating enzyme inhibitor, achieves antitumor effects against numerous malignancies. In this study, the s...

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Bibliographic Details
Main Authors: Meng-Huang Wu, Ching-Yu Lee, Tsung-Jen Huang, Kuo-Yuan Huang, Chih-Hsin Tang, Shing-Hwa Liu, Kuan-Lin Kuo, Feng-Che Kuan, Wei-Chou Lin, Chung-Sheng Shi
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:International Journal of Molecular Sciences
Subjects:
neddylation
NEDD8
chondrosarcoma
MLN4924
endoplasmic reticulum stress
ubiquitin-proteasome system
Online Access:http://www.mdpi.com/1422-0067/20/1/72

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http://www.mdpi.com/1422-0067/20/1/72

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