Streptococcus pneumoniae Attenuated Strain SPY1 with an Artificial Mineral Shell Induces Humoral and Th17 Cellular Immunity and Protects Mice against Pneumococcal Infection

Streptococcus pneumoniae Attenuated Strain SPY1 with an Artificial Mineral Shell Induces Humoral and Th17 Cellular Immunity and Protects Mice against Pneumococcal Infection

Streptococcus pneumoniae is a major pathogen leading to substantial morbidity and mortality in children under 5 years of age. Vaccination is an effective strategy to prevent S. pneumoniae infection. SPY1 is a pneumococcal vaccine candidate strain obtained in our previous study. To improve its stabil...

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Bibliographic Details
Main Authors: Xinyuan Zhang, Jingjing Cui, Yingying Wu, Hong Wang, Jian Wang, Yulan Qiu, Yunjun Mo, Yujuan He, Xuemei Zhang, Yibing Yin, Wenchun Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Immunology
Subjects:
Streptococcus pneumoniae
live attenuated vaccine
biomineralization
thermal stability
immunogenicity
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01983/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01983/full

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