Resolving Peto’s paradox: Modeling the potential effects of size‐related metabolic changes, and of the evolution of immune policing and cancer suppression
Abstract The intrinsic risk of cancer increases with body size and longevity; however, big long‐lived species do not exhibit this increase, a contradiction named Peto's paradox. Five hypotheses potentially resolving this paradox were modeled using the multistage model of carcinogenesis. The fiv...
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| Format: | Article |
| Language: | English |
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Wiley
2020-08-01
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| Series: | Evolutionary Applications |
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| Online Access: | https://doi.org/10.1111/eva.12993 |