The endogenous cardiotonic steroid Marinobufagenin and decline in estimated glomerular filtration rate at follow-up in patients with arterial hypertension.

The endogenous cardiotonic steroid Marinobufagenin and decline in estimated glomerular filtration rate at follow-up in patients with arterial hypertension.

<h4>Background</h4>Marinobufagenin (MBG) is an endogenous cardiotonic steroid (CTS) that inhibits the Na+/K+-ATPase. Human MBG is significantly increased in end-stage renal disease and immunization against MBG attenuates cardiovascular fibrosis in a rat model of uremic cardiomyopathy. Mi...

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Bibliographic Details
Main Authors: Martin H Keppel, Grzegorz Piecha, Winfried März, Janne Cadamuro, Simon Auer, Thomas K Felder, Cornelia Mrazek, Hannes Oberkofler, Christian Trummer, Martin R Grübler, Verena Schwetz, Nicolas Verheyen, Marlene Pandis, Valentin Borzan, Elisabeth Haschke-Becher, Andreas Tomaschitz, Stefan Pilz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0212973

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https://doi.org/10.1371/journal.pone.0212973

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