Complex Characterization of Germline Large Genomic Rearrangements of the <i>BRCA1</i> and <i>BRCA2</i> Genes in High-Risk Breast Cancer Patients—Novel Variants from a Large National Center

Complex Characterization of Germline Large Genomic Rearrangements of the <i>BRCA1</i> and <i>BRCA2</i> Genes in High-Risk Breast Cancer Patients—Novel Variants from a Large National Center

Large genomic rearrangements (LGRs) affecting one or more exons of <i>BRCA1</i> and <i>BRCA2</i> constitute a significant part of the mutation spectrum of these genes. Since 2004, the National Institute of Oncology, Hungary, has been involved in screening for LGRs of breast o...

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Bibliographic Details
Main Authors: Anikó Bozsik, Tímea Pócza, János Papp, Tibor Vaszkó, Henriett Butz, Attila Patócs, Edit Oláh
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:International Journal of Molecular Sciences
Subjects:
<i>BRCA1</i>
<i>BRCA2</i>
large genomic rearrangement
familial breast cancer
copy number analysis
breakpoint characterization
Online Access:https://www.mdpi.com/1422-0067/21/13/4650

Internet

https://www.mdpi.com/1422-0067/21/13/4650

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