Orbitofrontal-striatal potentiation underlies cocaine-induced hyperactivity
Psychomotor stimulants increase dopamine levels in the striatum and promote locomotion but their effects on striatal pathways in vivo remain unclear. The authors show that cocaine increases the activity of direct and indirect pathway striatal neurons of awake mice via the orbitofrontal cortex.
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2020-08-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-17763-8 |