A yeast two-hybrid system for the screening and characterization of small-molecule inhibitors of protein–protein interactions identifies a novel putative Mdm2-binding site in p53

A yeast two-hybrid system for the screening and characterization of small-molecule inhibitors of protein–protein interactions identifies a novel putative Mdm2-binding site in p53

Abstract Background Protein–protein interactions (PPIs) are fundamental to the growth and survival of cells and serve as excellent targets to develop inhibitors of biological processes such as host-pathogen interactions and cancer cell proliferation. However, isolation of PPI inhibitors is extremely...

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Bibliographic Details
Main Authors: Jin Huei Wong, Mohammad Alfatah, Mei Fang Sin, Hong May Sim, Chandra S. Verma, David P. Lane, Prakash Arumugam
Format: Article
Language:English
Published: BMC 2017-11-01
Series:BMC Biology
Subjects:
Yeast two-hybrid assay
Protein–protein interaction inhibitors
p53-Mdm2 interaction
Online Access:http://link.springer.com/article/10.1186/s12915-017-0446-7

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http://link.springer.com/article/10.1186/s12915-017-0446-7

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