Direct bacterial killing in vitro by recombinant Nod2 is compromised by Crohn's disease-associated mutations.

Direct bacterial killing in vitro by recombinant Nod2 is compromised by Crohn's disease-associated mutations.

<h4>Background</h4>A homeostatic relationship with the intestinal microflora is increasingly appreciated as essential for human health and wellbeing. Mutations in the leucine-rich repeat (LRR) domain of Nod2, a bacterial recognition protein, are associated with development of the inflamm...

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Bibliographic Details
Main Authors: Laurent-Herve Perez, Matt Butler, Tammy Creasey, JoAnn Dzink-Fox, John Gounarides, Stephanie Petit, Anna Ropenga, Neil Ryder, Kathryn Smith, Philip Smith, Scott J Parkinson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-06-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20531959/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20531959/?tool=EBI

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