Tryptophan catabolizing enzymes – party of three

Tryptophan catabolizing enzymes – party of three

Indoleamine 2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) are tryptophan-degrading enzymes that have independently evolved to catalyze the first step in tryptophan catabolism via the kynurenine pathway. The depletion of tryptophan and formation of kynurenine pathway metabolites modulate...

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Bibliographic Details
Main Authors: Helen J Ball, Felicita Fedelis Jusof, Supun Madushani Bakmiwewa, Nicholas H Hunt, Hajime eYuasa
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-10-01
Series:Frontiers in Immunology
Subjects:
Gene Duplication
Immunoregulation
convergent evolution
kynurenine pathway
divergent evolution
indoleamine 2
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00485/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00485/full

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