Reprogramming Intestinal Epithelial Cell Polarity by Interleukin-22

Reprogramming Intestinal Epithelial Cell Polarity by Interleukin-22

Background: Interleukin-22 (IL-22) impacts the integrity of intestinal epithelia and has been associated with the development of colitis-associated cancer and inflammatory bowel diseases (IBD). Previous data suggest that IL-22 protects the mucosal barrier and promotes wound healing and barrier defec...

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Bibliographic Details
Main Authors: Deborah Delbue, Lydia Lebenheim, Danielle Cardoso-Silva, Violaine Dony, Susanne M. Krug, Jan F. Richter, Subhakankha Manna, Melba Muñoz, Kerstin Wolk, Claudia Heldt, Markus M. Heimesaat, Robert Sabat, Britta Siegmund, Michael Schumann
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Medicine
Subjects:
intestinal epithelial cells
barrier function
cell polarity
IL-22
tight junctions
MAPK
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2021.656047/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2021.656047/full

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