Constitutive Expression of the Immunosuppressive Tryptophan Dioxygenase TDO2 in Glioblastoma Is Driven by the Transcription Factor C/EBPβ

Constitutive Expression of the Immunosuppressive Tryptophan Dioxygenase TDO2 in Glioblastoma Is Driven by the Transcription Factor C/EBPβ

Catabolism of the essential amino acid tryptophan is a key metabolic pathway contributing to the immunosuppressive tumor microenvironment and therefore a viable drug target for cancer immunotherapy. In addition to the rate-limiting enzyme indoleamine-2,3-dioxygenase-1 (IDO1), tryptophan catabolism v...

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Bibliographic Details
Main Authors: Takumi Kudo, Mirja T. Prentzell, Soumya R. Mohapatra, Felix Sahm, Zhongliang Zhao, Ingrid Grummt, Wolfgang Wick, Christiane A. Opitz, Michael Platten, Edward W. Green
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Immunology
Subjects:
TDO2
glioblastoma
regulation
CEBPB
tryptophan
IL1B
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00657/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00657/full

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