Spatially and Temporally Regulated NRF2 Gene Therapy Using Mcp-1 Promoter in Retinal Ganglion Cell Injury

Spatially and Temporally Regulated NRF2 Gene Therapy Using Mcp-1 Promoter in Retinal Ganglion Cell Injury

Retinal ganglion cell degeneration triggered by axonal injury is believed to underlie many ocular diseases, including glaucoma and optic neuritis. In these diseases, retinal ganglion cells are affected unevenly, both spatially and temporally, such that healthy and unhealthy cells coexist in differen...

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Bibliographic Details
Main Authors: Kosuke Fujita, Koji M. Nishiguchi, Yukihiro Shiga, Toru Nakazawa
Format: Article
Language:English
Published: Elsevier 2017-06-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
AAV gene therapy
Mcp-1
NRF2
oxidative stress
glaucoma
optic neuropathy
retina
Online Access:http://www.sciencedirect.com/science/article/pii/S232905011730058X

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http://www.sciencedirect.com/science/article/pii/S232905011730058X

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