Changes in the Expression of Aquaporin-3 in the Gastrointestinal Tract Affect Drug Absorption

Changes in the Expression of Aquaporin-3 in the Gastrointestinal Tract Affect Drug Absorption

Aquaporin-3 (AQP3) plays an important role in water transport in the gastrointestinal (GI) tract. In this study, we conducted a Caco-2 cell permeability assay to examine how changes in the expression and function of AQP3 affect the rate at which a drug is absorbed via passive transport in the GI tra...

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Bibliographic Details
Main Authors: Nobutomo Ikarashi, Chika Nagoya, Risako Kon, Satoshi Kitaoka, Sayuri Kajiwara, Masayo Saito, Akane Kawabata, Wataru Ochiai, Kiyoshi Sugiyama
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:International Journal of Molecular Sciences
Subjects:
aquaporin
Caco-2 cell
membrane fluidity
drug absorption
Online Access:https://www.mdpi.com/1422-0067/20/7/1559

Internet

https://www.mdpi.com/1422-0067/20/7/1559

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