Epigenetic–smoking interaction reveals histologically heterogeneous effects of TRIM27 DNA methylation on overall survival among early‐stage NSCLC patients

Epigenetic–smoking interaction reveals histologically heterogeneous effects of TRIM27 DNA methylation on overall survival among early‐stage NSCLC patients

Tripartite motif containing 27 (TRIM27) is highly expressed in lung cancer, including non‐small‐cell lung cancer (NSCLC). Here, we profiled DNA methylation of lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) tumours from 613 early‐stage NSCLC patients and evaluated associations bet...

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Bibliographic Details
Main Authors: Xinyu Ji, Lijuan Lin, Sipeng Shen, Xuesi Dong, Chao Chen, Yi Li, Ying Zhu, Hui Huang, Jiajin Chen, Xin Chen, Liangmin Wei, Jieyu He, Weiwei Duan, Li Su, Yue Jiang, Juanjuan Fan, Jinxing Guan, Dongfang You, Andrea Shafer, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, Yongyue Wei, Ruyang Zhang, Feng Chen, David C. Christiani
Format: Article
Language:English
Published: Wiley 2020-11-01
Series:Molecular Oncology
Subjects:
DNA methylation
interaction
non‐small‐cell lung cancer
overall survival
prognosis
TRIM27
Online Access:https://doi.org/10.1002/1878-0261.12785

Internet

https://doi.org/10.1002/1878-0261.12785

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