Combined effects of cigarette smoking, DNA methyltransferase 3B genetic polymorphism, and DNA damage on lung cancer

Combined effects of cigarette smoking, DNA methyltransferase 3B genetic polymorphism, and DNA damage on lung cancer

Abstract Background Smoking increases DNA methylation and DNA damage, and DNA damage acts as a vital cause of tumor development. The DNA methyltransferase 3B (DNMT3B) enhances promoter activity and methylation of tumor suppressor genes. Tea polyphenols may inhibit DNMT activity. We designed a case-c...

Full description

Bibliographic Details
Main Authors: Chia-Chen Huang, Chung-Yu Lai, Chin-Hung Tsai, Jiun-Yao Wang, Ruey-Hong Wong
Format: Article
Language:English
Published: BMC 2021-09-01
Series:BMC Cancer
Subjects:
Smoking
DNA damage
Green tea consumption
Lung cancer
DNMT3B genotype
Online Access:https://doi.org/10.1186/s12885-021-08800-w

Internet

https://doi.org/10.1186/s12885-021-08800-w

Similar Items