Identification of sonic hedgehog-regulated genes and biological processes in the cranial neural crest mesenchyme by comparative transcriptomics

Identification of sonic hedgehog-regulated genes and biological processes in the cranial neural crest mesenchyme by comparative transcriptomics

Abstract Background The evolutionarily conserved Sonic Hedgehog (Shh) signaling pathway is essential for embryogenesis and orofacial development. SHH ligand secreted from the surface ectoderm activates pathway activity in the underlying cranial neural crest cell (cNCC)-derived mesenchyme of the deve...

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Bibliographic Details
Main Authors: Joshua L. Everson, Dustin M. Fink, Hannah M. Chung, Miranda R. Sun, Robert J. Lipinski
Format: Article
Language:English
Published: BMC 2018-06-01
Series:BMC Genomics
Subjects:
Sonic hedgehog
Hedgehog target gene
Cranial neural crest cell
Frontonasal prominence
Medial nasal process
Orofacial development
Online Access:http://link.springer.com/article/10.1186/s12864-018-4885-5

Internet

http://link.springer.com/article/10.1186/s12864-018-4885-5

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