Association of filaggrin gene mutations and childhood eczema and wheeze with phthalates and phosphorus flame retardants in house dust: The Hokkaido study on Environment and Children's Health

Background and aim: Exposure to phthalates and phosphorus flame retardants (PFRs) is considered to be a risk factor for asthma and allergies. However, little is known about the contribution of loss-of-function mutations in the gene encoding filaggrin (FLG) gene, which are considered to be predisposi...

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Main Authors: Yu Ait Bamai, Atsuko Araki, Toshifumi Nomura, Toshio Kawai, Tazuru Tsuboi, Sumitaka Kobayashi, Chihiro Miyashita, Masae Takeda, Hiroshi Shimizu, Reiko Kishi
Format: Article
Language:English
Published: Elsevier 2018-12-01
Series:Environment International
Online Access:http://www.sciencedirect.com/science/article/pii/S0160412018309917