Pancreatic Cancer Signaling Pathways, Genetic Alterations, and Tumor Microenvironment: The Barriers Affecting the Method of Treatment

Pancreatic Cancer Signaling Pathways, Genetic Alterations, and Tumor Microenvironment: The Barriers Affecting the Method of Treatment

Genetic alterations, especially the K-Ras mutation, carry the heaviest burden in the progression of pancreatic precursor lesions into pancreatic ductal adenocarcinoma (PDAC). The tumor microenvironment is one of the challenges that hinder the therapeutic approaches from functioning sufficiently and...

Full description

Bibliographic Details
Main Authors: Darya Javadrashid, Amir Baghbanzadeh, Afshin Derakhshani, Patrizia Leone, Nicola Silvestris, Vito Racanelli, Antonio Giovanni Solimando, Behzad Baradaran
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Biomedicines
Subjects:
pancreatic cancer
pancreatic adenocarcinoma
PDAC
immune checkpoint
signaling pathway
gene mutation
Online Access:https://www.mdpi.com/2227-9059/9/4/373

Internet

https://www.mdpi.com/2227-9059/9/4/373

Similar Items