Uncovering the immunotherapeutic cycle initiated by p19Arf and interferon-β gene transfer to cancer cells: An inducer of immunogenic cell death

Simultaneous reestablishment of p53/p19Arf and interferon-β pathways in melanoma cells culminates in a cell death process that displays features of necroptosis along with the release of immunogenic cell death molecules and unleashes an antitumor immune response mediated by natural killer cells, neut...

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Bibliographic Details
Main Authors: Ruan F. V. Medrano, Aline Hunger, João P. P. Catani, Bryan E. Strauss
Format: Article
Language:English
Published: Taylor & Francis Group 2017-07-01
Series:OncoImmunology
Subjects:
p53
Online Access:http://dx.doi.org/10.1080/2162402X.2017.1329072