Uncovering the immunotherapeutic cycle initiated by p19Arf and interferon-β gene transfer to cancer cells: An inducer of immunogenic cell death

Simultaneous reestablishment of p53/p19Arf and interferon-β pathways in melanoma cells culminates in a cell death process that displays features of necroptosis along with the release of immunogenic cell death molecules and unleashes an antitumor immune response mediated by natural killer cells, neut...

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Main Authors:	Ruan F. V. Medrano, Aline Hunger, João P. P. Catani, Bryan E. Strauss
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2017-07-01
Series:	OncoImmunology
Subjects:	adenovirus gene therapy immunogenic cell death immunotherapy melanoma p53
Online Access:	http://dx.doi.org/10.1080/2162402X.2017.1329072

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spelling	doaj-116890c377ae4caca74755ea149b88d52020-11-25T03:03:03ZengTaylor & Francis GroupOncoImmunology2162-402X2017-07-016710.1080/2162402X.2017.13290721329072Uncovering the immunotherapeutic cycle initiated by p19Arf and interferon-β gene transfer to cancer cells: An inducer of immunogenic cell deathRuan F. V. Medrano0Aline Hunger1João P. P. Catani2Bryan E. Strauss3Cancer Institute of Sao Paulo/LIM 24, University of Sao Paulo School of MedicineCancer Institute of Sao Paulo/LIM 24, University of Sao Paulo School of MedicineCancer Institute of Sao Paulo/LIM 24, University of Sao Paulo School of MedicineCancer Institute of Sao Paulo/LIM 24, University of Sao Paulo School of MedicineSimultaneous reestablishment of p53/p19Arf and interferon-β pathways in melanoma cells culminates in a cell death process that displays features of necroptosis along with the release of immunogenic cell death molecules and unleashes an antitumor immune response mediated by natural killer cells, neutrophils as well as CD4+ and CD8+ T lymphocytes.http://dx.doi.org/10.1080/2162402X.2017.1329072adenovirusgene therapyimmunogenic cell deathimmunotherapymelanomap53
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Ruan F. V. Medrano Aline Hunger João P. P. Catani Bryan E. Strauss
spellingShingle	Ruan F. V. Medrano Aline Hunger João P. P. Catani Bryan E. Strauss Uncovering the immunotherapeutic cycle initiated by p19Arf and interferon-β gene transfer to cancer cells: An inducer of immunogenic cell death OncoImmunology adenovirus gene therapy immunogenic cell death immunotherapy melanoma p53
author_facet	Ruan F. V. Medrano Aline Hunger João P. P. Catani Bryan E. Strauss
author_sort	Ruan F. V. Medrano
title	Uncovering the immunotherapeutic cycle initiated by p19Arf and interferon-β gene transfer to cancer cells: An inducer of immunogenic cell death
title_short	Uncovering the immunotherapeutic cycle initiated by p19Arf and interferon-β gene transfer to cancer cells: An inducer of immunogenic cell death
title_full	Uncovering the immunotherapeutic cycle initiated by p19Arf and interferon-β gene transfer to cancer cells: An inducer of immunogenic cell death
title_fullStr	Uncovering the immunotherapeutic cycle initiated by p19Arf and interferon-β gene transfer to cancer cells: An inducer of immunogenic cell death
title_full_unstemmed	Uncovering the immunotherapeutic cycle initiated by p19Arf and interferon-β gene transfer to cancer cells: An inducer of immunogenic cell death
title_sort	uncovering the immunotherapeutic cycle initiated by p19arf and interferon-β gene transfer to cancer cells: an inducer of immunogenic cell death
publisher	Taylor & Francis Group
series	OncoImmunology
issn	2162-402X
publishDate	2017-07-01
description	Simultaneous reestablishment of p53/p19Arf and interferon-β pathways in melanoma cells culminates in a cell death process that displays features of necroptosis along with the release of immunogenic cell death molecules and unleashes an antitumor immune response mediated by natural killer cells, neutrophils as well as CD4+ and CD8+ T lymphocytes.
topic	adenovirus gene therapy immunogenic cell death immunotherapy melanoma p53
url	http://dx.doi.org/10.1080/2162402X.2017.1329072
work_keys_str_mv	AT ruanfvmedrano uncoveringtheimmunotherapeuticcycleinitiatedbyp19arfandinterferonbgenetransfertocancercellsaninducerofimmunogeniccelldeath AT alinehunger uncoveringtheimmunotherapeuticcycleinitiatedbyp19arfandinterferonbgenetransfertocancercellsaninducerofimmunogeniccelldeath AT joaoppcatani uncoveringtheimmunotherapeuticcycleinitiatedbyp19arfandinterferonbgenetransfertocancercellsaninducerofimmunogeniccelldeath AT bryanestrauss uncoveringtheimmunotherapeuticcycleinitiatedbyp19arfandinterferonbgenetransfertocancercellsaninducerofimmunogeniccelldeath
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Uncovering the immunotherapeutic cycle initiated by p19Arf and interferon-β gene transfer to cancer cells: An inducer of immunogenic cell death

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