Uncovering the immunotherapeutic cycle initiated by p19Arf and interferon-β gene transfer to cancer cells: An inducer of immunogenic cell death
Simultaneous reestablishment of p53/p19Arf and interferon-β pathways in melanoma cells culminates in a cell death process that displays features of necroptosis along with the release of immunogenic cell death molecules and unleashes an antitumor immune response mediated by natural killer cells, neut...
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2017-07-01
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Online Access: | http://dx.doi.org/10.1080/2162402X.2017.1329072 |
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doaj-116890c377ae4caca74755ea149b88d52020-11-25T03:03:03ZengTaylor & Francis GroupOncoImmunology2162-402X2017-07-016710.1080/2162402X.2017.13290721329072Uncovering the immunotherapeutic cycle initiated by p19Arf and interferon-β gene transfer to cancer cells: An inducer of immunogenic cell deathRuan F. V. Medrano0Aline Hunger1João P. P. Catani2Bryan E. Strauss3Cancer Institute of Sao Paulo/LIM 24, University of Sao Paulo School of MedicineCancer Institute of Sao Paulo/LIM 24, University of Sao Paulo School of MedicineCancer Institute of Sao Paulo/LIM 24, University of Sao Paulo School of MedicineCancer Institute of Sao Paulo/LIM 24, University of Sao Paulo School of MedicineSimultaneous reestablishment of p53/p19Arf and interferon-β pathways in melanoma cells culminates in a cell death process that displays features of necroptosis along with the release of immunogenic cell death molecules and unleashes an antitumor immune response mediated by natural killer cells, neutrophils as well as CD4+ and CD8+ T lymphocytes.http://dx.doi.org/10.1080/2162402X.2017.1329072adenovirusgene therapyimmunogenic cell deathimmunotherapymelanomap53 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ruan F. V. Medrano Aline Hunger João P. P. Catani Bryan E. Strauss |
spellingShingle |
Ruan F. V. Medrano Aline Hunger João P. P. Catani Bryan E. Strauss Uncovering the immunotherapeutic cycle initiated by p19Arf and interferon-β gene transfer to cancer cells: An inducer of immunogenic cell death OncoImmunology adenovirus gene therapy immunogenic cell death immunotherapy melanoma p53 |
author_facet |
Ruan F. V. Medrano Aline Hunger João P. P. Catani Bryan E. Strauss |
author_sort |
Ruan F. V. Medrano |
title |
Uncovering the immunotherapeutic cycle initiated by p19Arf and interferon-β gene transfer to cancer cells: An inducer of immunogenic cell death |
title_short |
Uncovering the immunotherapeutic cycle initiated by p19Arf and interferon-β gene transfer to cancer cells: An inducer of immunogenic cell death |
title_full |
Uncovering the immunotherapeutic cycle initiated by p19Arf and interferon-β gene transfer to cancer cells: An inducer of immunogenic cell death |
title_fullStr |
Uncovering the immunotherapeutic cycle initiated by p19Arf and interferon-β gene transfer to cancer cells: An inducer of immunogenic cell death |
title_full_unstemmed |
Uncovering the immunotherapeutic cycle initiated by p19Arf and interferon-β gene transfer to cancer cells: An inducer of immunogenic cell death |
title_sort |
uncovering the immunotherapeutic cycle initiated by p19arf and interferon-β gene transfer to cancer cells: an inducer of immunogenic cell death |
publisher |
Taylor & Francis Group |
series |
OncoImmunology |
issn |
2162-402X |
publishDate |
2017-07-01 |
description |
Simultaneous reestablishment of p53/p19Arf and interferon-β pathways in melanoma cells culminates in a cell death process that displays features of necroptosis along with the release of immunogenic cell death molecules and unleashes an antitumor immune response mediated by natural killer cells, neutrophils as well as CD4+ and CD8+ T lymphocytes. |
topic |
adenovirus gene therapy immunogenic cell death immunotherapy melanoma p53 |
url |
http://dx.doi.org/10.1080/2162402X.2017.1329072 |
work_keys_str_mv |
AT ruanfvmedrano uncoveringtheimmunotherapeuticcycleinitiatedbyp19arfandinterferonbgenetransfertocancercellsaninducerofimmunogeniccelldeath AT alinehunger uncoveringtheimmunotherapeuticcycleinitiatedbyp19arfandinterferonbgenetransfertocancercellsaninducerofimmunogeniccelldeath AT joaoppcatani uncoveringtheimmunotherapeuticcycleinitiatedbyp19arfandinterferonbgenetransfertocancercellsaninducerofimmunogeniccelldeath AT bryanestrauss uncoveringtheimmunotherapeuticcycleinitiatedbyp19arfandinterferonbgenetransfertocancercellsaninducerofimmunogeniccelldeath |
_version_ |
1724687157193342976 |