Neuronal Nsun2 deficiency produces tRNA epitranscriptomic alterations and proteomic shifts impacting synaptic signaling and behavior

Neuronal Nsun2 deficiency produces tRNA epitranscriptomic alterations and proteomic shifts impacting synaptic signaling and behavior

The link between tRNA modifications, protein translation, and behavior is unclear. Here, the authors show that neuronal Nsun2 deficiency results in codon-specific epitranscriptomic changes of Gly-tRNAs and proteomic changes affecting synaptic signaling and behavior in mice.

Bibliographic Details
Main Authors: J. Blaze, A. Navickas, H. L. Phillips, S. Heissel, A. Plaza-Jennings, S. Miglani, H. Asgharian, M. Foo, C. D. Katanski, C. P. Watkins, Z. T. Pennington, B. Javidfar, S. Espeso-Gil, B. Rostandy, H. Alwaseem, C. G. Hahn, H. Molina, D. J. Cai, T. Pan, W. D. Yao, H. Goodarzi, F. Haghighi, S. Akbarian
Format: Article
Language:English
Published: Nature Publishing Group 2021-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-24969-x

Internet

https://doi.org/10.1038/s41467-021-24969-x

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