Neuronal Nsun2 deficiency produces tRNA epitranscriptomic alterations and proteomic shifts impacting synaptic signaling and behavior
The link between tRNA modifications, protein translation, and behavior is unclear. Here, the authors show that neuronal Nsun2 deficiency results in codon-specific epitranscriptomic changes of Gly-tRNAs and proteomic changes affecting synaptic signaling and behavior in mice.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2021-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-24969-x |
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doaj-1173a6a94f8242d29268837ba49a821d2021-08-15T11:40:09ZengNature Publishing GroupNature Communications2041-17232021-08-0112111610.1038/s41467-021-24969-xNeuronal Nsun2 deficiency produces tRNA epitranscriptomic alterations and proteomic shifts impacting synaptic signaling and behaviorJ. Blaze0A. Navickas1H. L. Phillips2S. Heissel3A. Plaza-Jennings4S. Miglani5H. Asgharian6M. Foo7C. D. Katanski8C. P. Watkins9Z. T. Pennington10B. Javidfar11S. Espeso-Gil12B. Rostandy13H. Alwaseem14C. G. Hahn15H. Molina16D. J. Cai17T. Pan18W. D. Yao19H. Goodarzi20F. Haghighi21S. Akbarian22Department of Neuroscience, Icahn School of Medicine at Mt. SinaiDepartment of Biochemistry and Biophysics, University of California San FranciscoDepartments of Psychiatry and Behavioral Sciences, Neuroscience and Physiology, Upstate Medical UniversityThe Rockefeller University Proteomics Resource Center, The Rockefeller UniversityDepartment of Psychiatry, Icahn School of Medicine at Mt. SinaiDepartment of Biochemistry and Biophysics, University of California San FranciscoDepartment of Biochemistry and Biophysics, University of California San FranciscoDepartment of Biochemistry and Molecular Biology, University of ChicagoDepartment of Biochemistry and Molecular Biology, University of ChicagoDepartment of Biochemistry and Molecular Biology, University of ChicagoDepartment of Neuroscience, Icahn School of Medicine at Mt. SinaiFriedman Brain Institute, Icahn School of Medicine at Mt. SinaiFriedman Brain Institute, Icahn School of Medicine at Mt. SinaiThe Rockefeller University Proteomics Resource Center, The Rockefeller UniversityThe Rockefeller University Proteomics Resource Center, The Rockefeller UniversityDepartment of Neurosciences, Thomas Jefferson UniversityThe Rockefeller University Proteomics Resource Center, The Rockefeller UniversityDepartment of Neuroscience, Icahn School of Medicine at Mt. SinaiDepartment of Biochemistry and Molecular Biology, University of ChicagoDepartments of Psychiatry and Behavioral Sciences, Neuroscience and Physiology, Upstate Medical UniversityDepartment of Biochemistry and Biophysics, University of California San FranciscoDepartment of Neuroscience, Icahn School of Medicine at Mt. SinaiDepartment of Neuroscience, Icahn School of Medicine at Mt. SinaiThe link between tRNA modifications, protein translation, and behavior is unclear. Here, the authors show that neuronal Nsun2 deficiency results in codon-specific epitranscriptomic changes of Gly-tRNAs and proteomic changes affecting synaptic signaling and behavior in mice.https://doi.org/10.1038/s41467-021-24969-x |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
J. Blaze A. Navickas H. L. Phillips S. Heissel A. Plaza-Jennings S. Miglani H. Asgharian M. Foo C. D. Katanski C. P. Watkins Z. T. Pennington B. Javidfar S. Espeso-Gil B. Rostandy H. Alwaseem C. G. Hahn H. Molina D. J. Cai T. Pan W. D. Yao H. Goodarzi F. Haghighi S. Akbarian |
| spellingShingle |
J. Blaze A. Navickas H. L. Phillips S. Heissel A. Plaza-Jennings S. Miglani H. Asgharian M. Foo C. D. Katanski C. P. Watkins Z. T. Pennington B. Javidfar S. Espeso-Gil B. Rostandy H. Alwaseem C. G. Hahn H. Molina D. J. Cai T. Pan W. D. Yao H. Goodarzi F. Haghighi S. Akbarian Neuronal Nsun2 deficiency produces tRNA epitranscriptomic alterations and proteomic shifts impacting synaptic signaling and behavior Nature Communications |
| author_facet |
J. Blaze A. Navickas H. L. Phillips S. Heissel A. Plaza-Jennings S. Miglani H. Asgharian M. Foo C. D. Katanski C. P. Watkins Z. T. Pennington B. Javidfar S. Espeso-Gil B. Rostandy H. Alwaseem C. G. Hahn H. Molina D. J. Cai T. Pan W. D. Yao H. Goodarzi F. Haghighi S. Akbarian |
| author_sort |
J. Blaze |
| title |
Neuronal Nsun2 deficiency produces tRNA epitranscriptomic alterations and proteomic shifts impacting synaptic signaling and behavior |
| title_short |
Neuronal Nsun2 deficiency produces tRNA epitranscriptomic alterations and proteomic shifts impacting synaptic signaling and behavior |
| title_full |
Neuronal Nsun2 deficiency produces tRNA epitranscriptomic alterations and proteomic shifts impacting synaptic signaling and behavior |
| title_fullStr |
Neuronal Nsun2 deficiency produces tRNA epitranscriptomic alterations and proteomic shifts impacting synaptic signaling and behavior |
| title_full_unstemmed |
Neuronal Nsun2 deficiency produces tRNA epitranscriptomic alterations and proteomic shifts impacting synaptic signaling and behavior |
| title_sort |
neuronal nsun2 deficiency produces trna epitranscriptomic alterations and proteomic shifts impacting synaptic signaling and behavior |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2021-08-01 |
| description |
The link between tRNA modifications, protein translation, and behavior is unclear. Here, the authors show that neuronal Nsun2 deficiency results in codon-specific epitranscriptomic changes of Gly-tRNAs and proteomic changes affecting synaptic signaling and behavior in mice. |
| url |
https://doi.org/10.1038/s41467-021-24969-x |
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