Aldose reductase modulates acute activation of mesenchymal markers via the β-catenin pathway during cardiac ischemia-reperfusion.

Aldose reductase modulates acute activation of mesenchymal markers via the β-catenin pathway during cardiac ischemia-reperfusion.

Aldose reductase (AR: human, AKR1B1; mouse, AKR1B3), the first enzyme in the polyol pathway, plays a key role in mediating myocardial ischemia/reperfusion (I/R) injury. In earlier studies, using transgenic mice broadly expressing human AKR1B1 to human-relevant levels, mice devoid of Akr1b3, and phar...

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Bibliographic Details
Main Authors: Devi Thiagarajan, Karen O' Shea, Gopalkrishna Sreejit, Radha Ananthakrishnan, Nosirudeen Quadri, Qing Li, Ann Marie Schmidt, Kenneth Gabbay, Ravichandran Ramasamy
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5708684?pdf=render

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http://europepmc.org/articles/PMC5708684?pdf=render

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