β-amyloid controls altered Reelin expression and processing in Alzheimer's disease

β-amyloid controls altered Reelin expression and processing in Alzheimer's disease

Reelin is a glycoprotein that modulates synaptic function and plasticity in the mature brain, thereby favouring memory formation. We recently reported altered cerebral Reelin expression in Alzheimer's disease (AD). Here we demonstrate pronounced Reelin changes at protein and mRNA levels in the...

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Bibliographic Details
Main Authors: Arancha Botella-López, Inmaculada Cuchillo-Ibáñez, Tiziana Cotrufo, Su San Mok, Qiao-Xin Li, María-Sagrario Barquero, Mara Dierssen, Eduardo Soriano, Javier Sáez-Valero
Format: Article
Language:English
Published: Elsevier 2010-03-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
Down's syndrome
Amyloid
Reelin
Glycoprotein
Cerebral cortex
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996109003489

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http://www.sciencedirect.com/science/article/pii/S0969996109003489

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