Discrete levels of Twist activity are required to direct distinct cell functions during gastrulation and somatic myogenesis.

Twist (Twi), a conserved basic helix-loop-helix transcriptional regulator, directs the epithelial-to-mesenchymal transition (EMT), and regulates changes in cell fate, cell polarity, cell division and cell migration in organisms from flies to humans. Analogous to its role in EMT, Twist has been impli...

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Bibliographic Details
Main Authors: Ming-Ching Wong, Krista C Dobi, Mary K Baylies
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4051702?pdf=render