PD-L1 Deficiency within Islets Reduces Allograft Survival in Mice.

PD-L1 Deficiency within Islets Reduces Allograft Survival in Mice.

Islet transplantation may potentially cure type 1 diabetes mellitus (T1DM). However, immune rejection, especially that induced by the alloreactive T-cell response, remains a restraining factor for the long-term survival of grafted islets. Programmed death ligand-1 (PD-L1) is a negative costimulatory...

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Bibliographic Details
Main Authors: Dongxia Ma, Wu Duan, Yakun Li, Zhimin Wang, Shanglin Li, Nianqiao Gong, Gang Chen, Zhishui Chen, Chidan Wan, Jun Yang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4798758?pdf=render

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http://europepmc.org/articles/PMC4798758?pdf=render

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