Exploring monovalent and multivalent peptides for the inhibition of FBP21-tWW

Exploring monovalent and multivalent peptides for the inhibition of FBP21-tWW

The coupling of peptides to polyglycerol carriers represents an important route towards the multivalent display of protein ligands. In particular, the inhibition of low affinity intracellular protein–protein interactions can be addressed by this design. We have applied this strategy to develop bindi...

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Bibliographic Details
Main Authors: Lisa Maria Henning, Sumati Bhatia, Miriam Bertazzon, Michaela Marczynke, Oliver Seitz, Rudolf Volkmer, Rainer Haag, Christian Freund
Format: Article
Language:English
Published: Beilstein-Institut 2015-05-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
FBP21-tWW
isothermal titration calorimetry
multivalent polymers
polyglycerol peptide conjugates
proline-rich sequence recognition
Online Access:https://doi.org/10.3762/bjoc.11.80

Internet

https://doi.org/10.3762/bjoc.11.80

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