Phosphoproteomics of Acute Cell Stressors Targeting Exercise Signaling Networks Reveal Drug Interactions Regulating Protein Secretion

Summary: Exercise engages signaling networks to control the release of circulating factors beneficial to health. However, the nature of these networks remains undefined. Using high-throughput phosphoproteomics, we quantify 20,249 phosphorylation sites in skeletal muscle-like myotube cells and monito...

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Bibliographic Details
Main Authors: Elise J. Needham, Sean J. Humphrey, Kristen C. Cooke, Daniel J. Fazakerley, Xiaowen Duan, Benjamin L. Parker, David E. James
Format: Article
Language:English
Published: Elsevier 2019-11-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471931294X