Silencing PTEN in the fallopian tube promotes enrichment of cancer stem cell-like function through loss of PAX2

Silencing PTEN in the fallopian tube promotes enrichment of cancer stem cell-like function through loss of PAX2

Abstract High-grade serous ovarian cancer (HGSOC) is the most lethal gynecological malignancy that is primarily detected at the metastatic stage. Most HGSOC originates from the fallopian tube epithelium (FTE) and metastasizes to the ovary before invading the peritoneum; therefore, it is crucial to s...

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Bibliographic Details
Main Authors: Angela Russo, Jose A. Colina, Junlone Moy, Seth Baligod, Austin A. Czarnecki, Peter Varughese, Daniel D. Lantvit, Matthew J. Dean, Joanna E. Burdette
Format: Article
Language:English
Published: Nature Publishing Group 2021-04-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-03663-2

Internet

https://doi.org/10.1038/s41419-021-03663-2

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