Silencing PTEN in the fallopian tube promotes enrichment of cancer stem cell-like function through loss of PAX2
Abstract High-grade serous ovarian cancer (HGSOC) is the most lethal gynecological malignancy that is primarily detected at the metastatic stage. Most HGSOC originates from the fallopian tube epithelium (FTE) and metastasizes to the ovary before invading the peritoneum; therefore, it is crucial to s...
Main Authors: | Angela Russo, Jose A. Colina, Junlone Moy, Seth Baligod, Austin A. Czarnecki, Peter Varughese, Daniel D. Lantvit, Matthew J. Dean, Joanna E. Burdette |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2021-04-01
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Series: | Cell Death and Disease |
Online Access: | https://doi.org/10.1038/s41419-021-03663-2 |
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