Chromatin and Transcriptional Response to Loss of TBX1 in Early Differentiation of Mouse Cells

Chromatin and Transcriptional Response to Loss of TBX1 in Early Differentiation of Mouse Cells

The T-box transcription factor TBX1 has critical roles in the cardiopharyngeal lineage and the gene is haploinsufficient in DiGeorge syndrome, a typical developmental anomaly of the pharyngeal apparatus. Despite almost two decades of research, if and how TBX1 function triggers chromatin remodeling i...

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Bibliographic Details
Main Authors: Andrea Cirino, Ilaria Aurigemma, Monica Franzese, Gabriella Lania, Dario Righelli, Rosa Ferrentino, Elizabeth Illingworth, Claudia Angelini, Antonio Baldini
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
TBX1
chromatin accessibility
transcriptional response
DiGeorge syndrome
embryonic stell cell
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.571501/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2020.571501/full

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