Sphingosine kinase 1 activation by estrogen receptor α36 contributes to tamoxifen resistance in breast cancer

Sphingosine kinase 1 activation by estrogen receptor α36 contributes to tamoxifen resistance in breast cancer

In breast cancer, 17β-estradiol (E2) plays critical roles mainly by binding to its canonical receptor, estrogen receptor (ER) α66, and eliciting genomic effects. E2 also triggers rapid, nongenomic responses. E2 activates sphingosine kinase 1 (SphK1), increasing sphingosine-1-phosphate (S1P) that bin...

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Bibliographic Details
Main Authors: Melissa A. Maczis, Michael Maceyka, Michael R. Waters, Jason Newton, Manjulata Singh, Madisyn F. Rigsby, Tia H. Turner, Mohammad A. Alzubi, J. Chuck Harrell, Sheldon Milstien, Sarah Spiegel
Format: Article
Language:English
Published: Elsevier 2018-12-01
Series:Journal of Lipid Research
Subjects:
estradiol
estrogen receptor-α
splice variant
sphingosine-1-phosphate
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520341559

Internet

http://www.sciencedirect.com/science/article/pii/S0022227520341559

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