Inhibition of the STAT3 Signaling Pathway Contributes to the Anti-Melanoma Activities of Shikonin

Inhibition of the STAT3 Signaling Pathway Contributes to the Anti-Melanoma Activities of Shikonin

BackgroundMalignant melanoma is an extremely aggressive and metastatic cancer, and highly resistant to conventional therapies. Signal transducer and activator of transcription 3 (STAT3) signaling promotes melanoma development and progression, which has been validated as an effective target in melano...

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Bibliographic Details
Main Authors: Hui-Hui Cao, Dong-Yi Liu, Ye-Cai Lai, Yu-Yao Chen, Lin-Zhong Yu, Meng Shao, Jun-Shan Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Pharmacology
Subjects:
shikonin
melanoma
apoptosis
migration
invasion
STAT3
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00748/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00748/full

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