Construction and characterisation of a complete reverse genetics system of dengue virus type 3

Dengue virulence and fitness are important factors that determine disease outcome. However, dengue virus (DENV) molecular biology and pathogenesis are not completely elucidated. New insights on those mechanisms have been facilitated by the development of reverse genetic systems in the past decades....

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Bibliographic Details
Main Authors: Jefferson Jose da Silva Santos, Marli Tenorio Cordeiro, Giovani Rota Bertani, Ernesto Torres de Azevedo Marques, Laura Helena Vega Gonzales Gil
Format: Article
Language:English
Published: Instituto Oswaldo Cruz, Ministério da Saúde 2013-12-01
Series:Memórias do Instituto Oswaldo Cruz.
Subjects:
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762013000800983&lng=en&tlng=en