Tanshinol Alleviates Microcirculation Disturbance and Impaired Bone Formation by Attenuating TXNIP Signaling in GIO Rats

Tanshinol Alleviates Microcirculation Disturbance and Impaired Bone Formation by Attenuating TXNIP Signaling in GIO Rats

Impaired bone formation is the main characteristics of glucocorticoid (GC)-induced osteoporosis (GIO), which can be ameliorated by tanshinol, an aqueous polyphenol isolated from Salvia miltiorrhiza Bunge. However, the underlying mechanism is still not entirely clear. In the present study, we determi...

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Bibliographic Details
Main Authors: Wenxiu Lai, Yulin Mo, Dongtao Wang, Ying Zhong, Lujiao Lu, Jiajia Wang, Liao Cui, Yanzhi Liu, Yajun Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Pharmacology
Subjects:
GIO
TXNIP (thioredoxin interacting protein)
VEGF (vascular endothelial growth factor)
β-catenin (CTNNB1)
microcirculation dysfunction
bone metabolism
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.722175/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.722175/full

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