Differentiation of human induced pluripotent stem cells into nucleus pulposus-like cells

Differentiation of human induced pluripotent stem cells into nucleus pulposus-like cells

Abstract Background Intervertebral disc (IVD) degeneration is characterized by an early decrease in cellularity of the nucleus pulposus (NP) region, and associated extracellular matrix changes, reduced hydration, and progressive degeneration. Cell-based IVD therapy has emerged as an area of great in...

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Bibliographic Details
Main Authors: Ruhang Tang, Liufang Jing, Vincent P. Willard, Chia-lung Wu, Farshid Guilak, Jun Chen, Lori A. Setton
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Stem Cell Research & Therapy
Subjects:
Human induced pluripotent stem cells
Intervertebral disc
Degenerative disc disease
Nucleus pulposus
Directed differentiation
Chondrocyte
Online Access:http://link.springer.com/article/10.1186/s13287-018-0797-1

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http://link.springer.com/article/10.1186/s13287-018-0797-1

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