Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity

Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity

Tuberculosis meningitis (TBM) is a severe form of TB with limited treatment options. Here, the authors perform RNA sequencing on whole blood and on ventricular and lumbar cerebrospinal fluid (CSF) samples from pediatric patients treated for TBM to characterize the immune response and tissue damage.

Bibliographic Details
Main Authors: Ursula K. Rohlwink, Anthony Figaji, Katalin A. Wilkinson, Stuart Horswell, Abdul K. Sesay, Armin Deffur, Nico Enslin, Regan Solomons, Ronald Van Toorn, Brian Eley, Michael Levin, Robert J. Wilkinson, Rachel P. J. Lai
Format: Article
Language:English
Published: Nature Publishing Group 2019-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-11783-9

Internet

https://doi.org/10.1038/s41467-019-11783-9

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