The Significance of the DUF283 Domain for the Activity of Human Ribonuclease Dicer

The Significance of the DUF283 Domain for the Activity of Human Ribonuclease Dicer

Dicers are multidomain proteins, usually comprising an amino-terminal putative helicase domain, a DUF283 domain (domain of unknown function), a PAZ domain, two RNase III domains (RNase IIIa and RNase IIIb) and a dsRNA-binding domain. Dicer homologs play an important role in the biogenesis of small r...

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Bibliographic Details
Main Authors: Agnieszka Szczepanska, Marta Wojnicka, Anna Kurzynska-Kokorniak
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
Dicer
RNase III
nucleic acid annealers
RNA-binding proteins
RNA-RNA base pairing
RNA cleavage activity
Online Access:https://www.mdpi.com/1422-0067/22/16/8690

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https://www.mdpi.com/1422-0067/22/16/8690

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