The necrotic signal induced by mycophenolic acid overcomes apoptosis-resistance in tumor cells.

The necrotic signal induced by mycophenolic acid overcomes apoptosis-resistance in tumor cells.

BACKGROUND: The amount of inosine monophosphate dehydrogenase (IMPDH), a pivotal enzyme for the biosynthesis of the guanosine tri-phosphate (GTP), is frequently increased in tumor cells. The anti-viral agent ribavirin and the immunosuppressant mycophenolic acid (MPA) are potent inhibitors of IMPDH....

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Main Authors: Gwendaline Guidicelli, Benjamin Chaigne-Delalande, Marie-Sarah Dilhuydy, Benoît Pinson, Walid Mahfouf, Jean-Max Pasquet, François-Xavier Mahon, Philippe Pourquier, Jean-François Moreau, Patrick Legembre
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2675064?pdf=render

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http://europepmc.org/articles/PMC2675064?pdf=render

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