Nucleoside analogue activators of cyclic AMP-independent protein kinase A of Trypanosoma

Nucleoside analogue activators of cyclic AMP-independent protein kinase A of Trypanosoma

Protein kinase A (PKA) is typically activated by cAMP. Here, Bachmaier et al. show that PKA of Trypanosoma is activated by nucleoside-related ligands, explain the ligand selectivity swap by a co-crystal structure of trypanosome PKAR, and identify potential downstream targets by phosphoproteomics.

Bibliographic Details
Main Authors: Sabine Bachmaier, Yuri Volpato Santos, Susanne Kramer, George Boniface Githure, Thomas Klöckner, Julia Pepperl, Cordula Baums, Robin Schenk, Frank Schwede, Hans-Gottfried Genieser, Jean-William Dupuy, Ignasi Forné, Axel Imhof, Jerôme Basquin, Esben Lorentzen, Michael Boshart
Format: Article
Language:English
Published: Nature Publishing Group 2019-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-09338-z

Internet

https://doi.org/10.1038/s41467-019-09338-z

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