Telocinobufagin and Marinobufagin Produce Different Effects in LLC-PK1 Cells: A Case of Functional Selectivity of Bufadienolides

Telocinobufagin and Marinobufagin Produce Different Effects in LLC-PK1 Cells: A Case of Functional Selectivity of Bufadienolides

Bufadienolides are cardiotonic steroids (CTS) identified in mammals. Besides Na+/K+-ATPase inhibition, they activate signal transduction via protein–protein interactions. Diversity of endogenous bufadienolides and mechanisms of action may indicate the presence of functional selectivity and...

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Bibliographic Details
Main Authors: Luciana S. Amaral, Jainne Martins Ferreira, Danilo Predes, José Garcia Abreu, François Noël, Luis Eduardo M. Quintas
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:International Journal of Molecular Sciences
Subjects:
cardiotonic steroids
bufadienolides
Na+/K+-ATPase
functional selectivity
ERK1/2
GSK-3β
Wnt/β-catenin pathway
Online Access:http://www.mdpi.com/1422-0067/19/9/2769

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http://www.mdpi.com/1422-0067/19/9/2769

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