CXCR4 and CXCR7 play distinct roles in cardiac lineage specification and pharmacologic β-adrenergic response

CXCR4 and CXCR7 play distinct roles in cardiac lineage specification and pharmacologic β-adrenergic response

CXCR4 and CXCR7 are prominent G protein-coupled receptors (GPCRs) for chemokine stromal cell-derived factor-1 (SDF-1/CXCL12). This study demonstrates that CXCR4 and CXCR7 induce differential effects during cardiac lineage differentiation and β-adrenergic response in human induced pluripotent stem ce...

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Bibliographic Details
Main Authors: Delaine K. Ceholski, Irene C. Turnbull, Venu Pothula, Laura Lecce, Andrew A. Jarrah, Changwon Kho, Ahyoung Lee, Lahouaria Hadri, Kevin D. Costa, Roger J. Hajjar, Sima T. Tarzami
Format: Article
Language:English
Published: Elsevier 2017-08-01
Series:Stem Cell Research
Subjects:
CXCR4
CXCR7
Cardiogenesis
hiPSC
Engineered tissue
Online Access:http://www.sciencedirect.com/science/article/pii/S187350611730123X

Internet

http://www.sciencedirect.com/science/article/pii/S187350611730123X

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