Connexin-43-dependent ATP release mediates macrophage activation during sepsis

Connexin-43-dependent ATP release mediates macrophage activation during sepsis

Bacterial spillage into a sterile environment following intestinal hollow-organ perforation leads to peritonitis and fulminant sepsis. Outcome of sepsis critically depends on macrophage activation by extracellular ATP-release and associated autocrine signalling via purinergic receptors. ATP-release...

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Bibliographic Details
Main Authors: Michel Dosch, Joël Zindel, Fadi Jebbawi, Nicolas Melin, Daniel Sanchez-Taltavull, Deborah Stroka, Daniel Candinas, Guido Beldi
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-02-01
Series:eLife
Subjects:
sepsis
macrophages
purinergic signaling
ATP release
Connexin-43
Online Access:https://elifesciences.org/articles/42670

Internet

https://elifesciences.org/articles/42670

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