Robust rat pulmonary radioprotection by a lipophilic Mn N-alkylpyridylporphyrin, MnTnHex-2-PyP5+

Robust rat pulmonary radioprotection by a lipophilic Mn N-alkylpyridylporphyrin, MnTnHex-2-PyP5+

With the goal to enhance the distribution of cationic Mn porphyrins within mitochondria, the lipophilic Mn(III)meso-tetrakis(N-n-hexylpyridinium-2-yl)porphyrin, MnTnHex-2-PyP5+ has been synthesized and tested in several different model of diseases, where it shows remarkable efficacy at as low as 50...

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Bibliographic Details
Main Authors: Benjamin Gauter-Fleckenstein, Julio S. Reboucas, Katharina Fleckenstein, Artak Tovmasyan, Kouros Owzar, Chen Jiang, Ines Batinic-Haberle, Zeljko Vujaskovic
Format: Article
Language:English
Published: Elsevier 2014-01-01
Series:Redox Biology
Subjects:
Radioprotection
Fischer rats
Manganese porphyrins
MnTnHex-2-PyP5+
MnTE-2-PyP5+
Redox-modulators
Lung injury
Immunohistochemistry
Histopathology
Breathing frequencies
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231713001055

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http://www.sciencedirect.com/science/article/pii/S2213231713001055

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