The Prospect of Identifying Resistance Mechanisms for Castrate-Resistant Prostate Cancer Using Circulating Tumor Cells: Is Epithelial-to-Mesenchymal Transition a Key Player?

Prostate cancer (PCa) is initially driven by excessive androgen receptor (AR) signaling with androgen deprivation therapy (ADT) being a major therapeutic approach to its treatment. However, the development of drug resistance is a significant limitation on the effectiveness of both first-line and mor...

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Bibliographic Details
Main Authors: Tanzila Khan, Kieran F. Scott, Therese M. Becker, John Lock, Mohammed Nimir, Yafeng Ma, Paul de Souza
Format: Article
Language:English
Published: Hindawi Limited 2020-01-01
Series:Prostate Cancer
Online Access:http://dx.doi.org/10.1155/2020/7938280