Integrin alpha11 is an Osteolectin receptor and is required for the maintenance of adult skeletal bone mass

Integrin alpha11 is an Osteolectin receptor and is required for the maintenance of adult skeletal bone mass

We previously discovered a new osteogenic growth factor that is required to maintain adult skeletal bone mass, Osteolectin/Clec11a. Osteolectin acts on Leptin Receptor+ (LepR+) skeletal stem cells and other osteogenic progenitors in bone marrow to promote their differentiation into osteoblasts. Here...

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Bibliographic Details
Main Authors: Bo Shen, Kristy Vardy, Payton Hughes, Alpaslan Tasdogan, Zhiyu Zhao, Rui Yue, Genevieve M Crane, Sean J Morrison
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-01-01
Series:eLife
Subjects:
osteogenesis
Osteolectin
skeletal stem cell
integrin
bone
Wnt signaling
Online Access:https://elifesciences.org/articles/42274

Internet

https://elifesciences.org/articles/42274

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