Integrin alpha11 is an Osteolectin receptor and is required for the maintenance of adult skeletal bone mass
We previously discovered a new osteogenic growth factor that is required to maintain adult skeletal bone mass, Osteolectin/Clec11a. Osteolectin acts on Leptin Receptor+ (LepR+) skeletal stem cells and other osteogenic progenitors in bone marrow to promote their differentiation into osteoblasts. Here...
Main Authors: | Bo Shen, Kristy Vardy, Payton Hughes, Alpaslan Tasdogan, Zhiyu Zhao, Rui Yue, Genevieve M Crane, Sean J Morrison |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2019-01-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/42274 |
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