In Vitro and In Vivo Synergistic Therapeutic Effect of Cisplatin with Human Papillomavirus16 E6/E7 CRISPR/Cas9 on Cervical Cancer Cell Line

PURPOSE: Human papillomavirus (HPV) type 16 is one of the major etiologic factors of cervical cancer. Our study aims to investigate the potentiality of the antiviral clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated Cas9 system (CRISPR/Cas9) targeting the E6 and E7...

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Bibliographic Details
Main Authors: Shuai Zhen, Jiao-Jiao Lu, Li-Jie Wang, Xiao-Min Sun, Jia-Qi Zhang, Xu Li, Wen-Juan Luo, Le Zhao
Format: Article
Language:English
Published: Elsevier 2016-12-01
Series:Translational Oncology
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523316301668