Drug Sensitivity Screening and Targeted Pathway Analysis Reveal a Multi-Driver Proliferative Mechanism and Suggest a Strategy of Combination Targeted Therapy for Colorectal Cancer Cells

Drug Sensitivity Screening and Targeted Pathway Analysis Reveal a Multi-Driver Proliferative Mechanism and Suggest a Strategy of Combination Targeted Therapy for Colorectal Cancer Cells

Treatment of colorectal cancer mostly relies on traditional therapeutic approaches, such as surgery and chemotherapy. Limited options of targeted therapy for colorectal cancer narrowly focus on blocking cancer-generic targets VEGFR and EGFR. Identifying the oncogenic drivers, understanding their con...

Full description

Bibliographic Details
Main Authors: Jinyan Shen, Li Li, Tao Yang, Niuliang Cheng, Gongqin Sun
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:Molecules
Subjects:
colorectal cancer
combination therapy
dose reduction index
protein kinase inhibitors
targeted therapy
Online Access:https://www.mdpi.com/1420-3049/24/3/623

Internet

https://www.mdpi.com/1420-3049/24/3/623

Similar Items